Emissions of soot particles exert crucial impact on human health and the environment. Previous researches show that a partial replacement of fossil fuels with oxygenated fuels is supposed to reduce soot emission. However, the crucial information of soot size distributions is unclear, although small particles are more dangerous than large particles. In this paper, dimethyl ether (DME) is selected among the oxygenated fuels for the investigation of the doping effect on nascent soot formation. DME was doped in the burner-stabilized rich premixed ethylene/oxygen/argon flames at various mixing ratios. Flame temperature profiles were measured using R-type thermocouples with radiation correction. A scanning mobility particle sizer (SMPS) with a sampling system was used to determine particle size distributions (PSDs) of soot-containing combustion products with immediate dilution. Thermo-gravimetric analysis (TGA) complemented with elemental analysis (EA) was conducted to detect the chemical properties of formed soot particles. Additionally, species profiles of the experimental flame conditions were provided from simulations. The experimental PSDs showed that DME addition could slow down soot evolution process, while lead to a slight increase in incipient soot with size below 4 nm. When DME added, the production of benzene was suppressed due to the reduced concentrations of acetylene and propargyl, and thus soot nucleation. Meanwhile, soot oxidiation was enhanced because the OH radical and the oxidizability of soot particles are both increased. Considering the slight increase of sub-4 nm soot, the effect of oxygenated-PAHs (OPAH) was emphasized. The production of OPAH suppressed soot surface growth, which leading to the relatively lower consumption of sub-4 nm soot in DME added flames.